Synthetic · 18th century to present

Prussian blue, first produced in Berlin around 1706, is widely credited as the first modern synthetic pigment.
The glass dish and pale backdrop occupy more of the frame than the pigment itself, so an automated whole-frame scan would be dominated by grey and white rather than the blue pigment — the palette above was hand-picked from the pigment mound."Pigment Berliner Blau" by Saalebaer, CC0, via Wikimedia CommonsLow toxicity
Contains iron-cyanide compounds that are chemically stable and generally considered low-risk in normal use, unlike free cyanide.
The cyanide compound is tightly chemically bound and considered low-risk in normal artistic and industrial use; still used safely in modern artists' paint.